The Relationship between Hyperhomocysteinemia, Haemostatic Factors and Acute Coronary Syndrome in Southeastern Turkey: A Prospective, Comparative Study

Aim: We investigated the relationship between hyperhomocysteinemia, coagulation factors and acute coronary syndrome. Materials and method: The study was conducted at cardiology and hematology department of Dicle University Medical School between January 1 2003 and May 31 2009. The study included 96 patients with acute coronary syndrome and 96 controls. Results: Baseline characteristics of patients (63 males, 33 females, mean age: 56.4 years) and controls (58 males and 38 females, mean age: 51.1 years) were similar. There was a statistically significant difference between two groups according to homocysteine levels (13.4 ± 8.0 micromole/L vs. 12.8 ± 7.1 micromole/L p = 0.042). In this study, we found that hyperhomocysteinemia, smoking, elevated levels of CRP, low levels of HDL, positive family history, presence of hypertension, BMI > 27, low levels of protein C and protein S were associated with high risk for acute coronary syndrome. Fibrinogen level, factor V level, factor VIII level, factor IX level ,factor X level ,and factor V leiden (p = 0.128) are not risk factors for acute coronary syndrome. Conclusion: Hyperhomocysteine is a significant risk factor for acute coronary syndrome. There is not relationship between coagulation factors and acute coronary syndrome except low levels of protein C and protein S.